Caveolin 1-Reporter Protein Knock-In Mouse
AssigneeTrustees of Dartmouth College
InventorRadu V. Stan
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Abstract
The present invention embraces a transgenic mouse whose genome harbors a nucleic acid molecule encoding caveolin-1 fused in-frame with a reporter. To control expression of the Cav1-reporter, the nucleic acid molecule further includes a selectable marker expression cassette flanked by recombinase target sites in such a manner that, upon exposure to recombinase, said selectable marker expression cassette is excised from said nucleic acid molecule.
Claims8
A transgenic mouse whose genome comprises a nucleic acid molecule encoding caveolin-1 fused in-frame with a reporter protein, wherein said nucleic acid molecule further includes a selectable marker expression cassette flanked by recombinase target sites in such a manner that, upon exposure to recombinase, said selectable marker expression cassette is excised from said nucleic acid molecule.
Dependencies are inferred from the claim text.