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US 2012/0060230 A1Published application
Methods and compositions for modification of a hla locus
AssigneesSangamo BioSciences, Inc., Board of Regents, The University of Texas Systems
InventorsTrevor Collingwood, Laurence J.N. Cooper, Philip D. Gregory, Michael C. Holmes, Jeffrey C. Miller, Edward J. Rebar, Andreas Reik, Fyodor Urnov
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Abstract
Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator.
Claims26
An isolated polypeptide comprising a non-naturally occurring zinc finger protein that binds to a target site as shown in Table 2 in an endogenous gene.
The fusion protein 2, wherein the functional domain comprises a cleavage domain or cleavage half-domain.
Dependencies are inferred from the claim text.