Vibration induced in vivo substance targeting
OwnerRao Papineniinventor
Life of this patent
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Abstract
A method for aggregating a substance in a localized region within a body of an animal comprises applying a vibration pattern that causes aggregation of the substance to the localized region within the body of the animal, introducing the substance and aggregating the substance in the localized region based upon application of the vibration pattern. The substance, which may be a drug, fluorescent dye, conjugate of the two or a smart probe, may aggregate to bone, specifically to the lumbar region of the spine. About two to about four times more substance may aggregate in the localized region of the body relative to a control where no vibration pattern is applied.
Claims20
A method for aggregating a substance in a localized region within a body of an animal, comprising:
- applying a vibration pattern that causes aggregation of the substance to the localized region within the body of the animal;
- introducing the substance into the body of the animal;
- and
- aggregating the substance in the localized region based upon application of the vibration pattern.
A method of aggregating a substance in a localized region within a body of an animal, comprising:
- applying a vibration pattern that causes aggregation of the substance to the localized region within the body of the animal, wherein the localized region is the lumbar region;
- subjecting the body of the animal to the vibration pattern;
- introducing the substance into the body of the animal;
- and
- aggregating the substance in the lumbar region based upon the vibration pattern.
A method of aggregating a substance in a localized region within a body of an animal, comprising:
- applying a vibration pattern that causes aggregation of the substance to the localized region within the body of the animal;
- introducing the substance into the body of the animal;
- and
- aggregating the substance in the localized region based upon the vibration pattern, wherein between about two to about four times more substance aggregates in the localized region of the body relative to a control where no vibration pattern is applied.
Dependencies are inferred from the claim text.