Method for preparation of micellar hybrid nanoparticles for therapeutic and diagnostic applications and compositions thereof
AssigneesMassachusetts Institute of Technology, The Regents of the University of California
InventorsMichael J. Sailor, Sangeeta N. Bhatia, Ji-Ho Park, Geoffrey A. Von Maltzahn
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Abstract
The disclosure provides a long-circulating, micellar hybrid nanoparticles (MHN) that contain MN, QD, and the anti-cancer drug doxorubicin (DOX) within a single polyethylene glycol (PEG)-phospholipid micelle and provide the first examples of simultaneous targeted drug delivery and dual-mode NIR-fluorescent and MR imaging of diseased tissue in vitro and in vivo.
Claims19
A micelle compositions encapsulating a plurality of different nanostructures at least two of the plurality of nanostructures having different excitation/emission spectrums or detectable signals.
A method of making a pegylated-micelle-nanostructure composition comprising:
- evaporating a mixture comprising pegylated lipids, at least one nanostructure, at least one quantum dot and an organic solvent to obtain a dry mixture;
- hydrating the dry mixture in a hydrating medium to obtain a pegylated-micelle-nanostructure composition, wherein the nanostructure and quantum dot are encapsulated within the micelle.
Dependencies are inferred from the claim text.