Methods for detecting endometriosis
AssigneeThe Research Foundation of State University of New York
InventorOzgul Muneyyirci-Delale
Life of this patent
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Abstract
The method of the present invention is directed towards detecting endometriosis in a mammalian subject. This method comprises the following steps; taking a sample from the mammal, measuring the level of sphingomyelin (SM) or phosphatidylcholine (PC), or combinations thereof, in the sample, comparing the measured levels of SM or PC, or combinations thereof, to predetermined levels, and diagnosing the mammal based on the comparison. This method may also comprise the following steps: taking a sample from the mammal, measuring the level of F11 Receptor (F11R) in the sample, comparing the measured level of F11R to a predetermined level, and diagnosing the mammal based on the comparison.
Claims29
A method of detecting endometriosis in a mammal comprising:
- taking a sample from the mammal;
- measuring the level of sphingomyelin (SM) or phosphatidylcholine (PC), or combinations thereof, in the sample;
- comparing the measured levels of SM or PC, or combinations thereof, to predetermined levels;
- and
- diagnosing the mammal based on the comparison.
The method of claim wherein a diagnosis of having endometriosis is given if a measured SM level is about 20% lower than the predetermined level and a measured PC level is about 23% lower than the predetermined level.
A kit for diagnosing endometriosis in a mammal comprising:
- a sampler, an assay capable of determining the level of SM, PC, or combinations thereof in a sample, components for performing the assay, and a predetermined level of SM, PC, or combinations thereof for comparison.
A method of detecting endometriosis in a mammal comprising:
- taking a sample from the mammal;
- measuring the level of F11 Receptor (F11R) in the sample;
- comparing the measured level of F11R to a predetermined level;
- and
- diagnosing the mammal based on the comparison.
The method of claim 21 wherein the sample is taken during the early follicular phase of the mammal's menstrual cycle.
The method of claim 25 wherein the sample is blood.
A kit for diagnosing endometriosis in a mammal comprising:
- a sampler, an assay capable of determining F11R levels in a sample, and a predetermined level of F11R for comparison.
The kit of claim 28 wherein the assay is selected from the group consisting of an enzyme-linked immunosorbent assay (ELBA), immunofluorescence, immunohistochemistry and a Western blot.
Dependencies are inferred from the claim text.