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US 2012/0059177 A1Published application
Method for producing 2-substituted tetrahydropyranols
AssigneeBASF SE
InventorsGabriele Gralla, Ralf Pelzer, Klaus Ebel, Ulrich Griesbach, Jörg Botzem
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Abstract
The present invention relates to a process for the preparation of 2-substituted 4-hydroxy-4-methyltetrahydropyranols by reacting 3-methylbut-3-en-1-ol (isoprenol) with the corresponding aldehydes in the presence of a strongly acidic cation exchanger. Specifically, the present invention relates to a corresponding process for the preparation of 2-isobutyl-4-hydroxy-4-methyltetrahydropyran by reacting isoprenol with isovaleraldehyde.
Claims16
1-15. (canceled)
A process for the preparation of 2-substituted 4-hydroxy-4-methyltetrahydropyrans of the formula (I)
- where the radical
- R1 is a straight-chain or branched alkyl or alkenyl radical having 1 to 12 carbon atoms, an optionally alkyl-substituted cycloalkyl radical having in total 3 to 12 carbon atoms or an optionally alkyl- and/or alkoxy-substituted aryl radical having in total 6 to 12 carbon atoms,
- said process comprising reacting 3-methylbut-3-en-1-ol of the formula (II)
- with an aldehyde of the formula (III)
- R1—CHO (III),
- wherein the radical R1 has the same meaning as in formula (I) and
- wherein the reaction is carried out in the presence of water and in the presence of a strongly acidic cation exchanger.
4 more elements
Dependencies are inferred from the claim text.