Dendritic molecules
AssigneeThe University of Queensland
InventorsMichael John Monteiro, Michael Raymond Whittaker, Craig Andrew Bell, Carl N. Urbani, Daria Eden Lonsdale
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Abstract
The invention relates to novel dendritic molecules and methods of making them. The dendritic molecules comprise arms, each of which arms is a polymer. The dendritic molecules can be synthesised by way of a reasonably small number of versatile and reliable step-wise reactions, especially click chemistry reactions. Chemical and structural heterogeneity is possible in the dendritic molecule. The invention also provides for surface and interior functionalisation of the molecule.
Claims40
1-37. (canceled)
A dendron including:
- a first polymer;
- two or more first generation polymers bound to the first polymer;
- and
- wherein the first generation polymers include a functional group having at least one active site capable of bonding to a complementary functional group having at least one active site of a predetermined number of further generation polymers, and wherein the first polymer includes a functional group having at least one active site capable of bonding to a complementary functional group having at least one active site of another dendron.
A dendritic molecule comprising:
- a core or first polymer that is a star polymer comprising three or more arms, at least one arm comprising a functional group having an active site;
- and
- one or more generation polymers or one or more dendrons bound to the active site.
A method of forming a dendron comprising the steps of:
- (a) forming a first polymer comprising a functional group having at least one active site;
- (b) bonding at least one first generation polymer to the at least one active site of the first polymer to form a first generation macromolecule, said first generation polymer comprising at least one functional group having at least one active site;
- (c) bonding at least one further generation polymer to the at least one active site of the first generation polymer to form a second generation macromolecule;
- and
- (d) wherein said further generation polymer includes at least one functional group having at least one active site capable of bonding to at least a further generation polymer.
A method of convergently forming a dendritic molecule comprising the steps of:
- (a) forming a plurality of dendrons, each dendron being formed by the steps of
- (1) forming a first polymer,
- (2) bonding a functional group having at least one active site to the polymer,
- (3) bonding at least one generation polymer to the at least one active of the polymer to form a first generation macromolecule,
- (4) bonding a functional group having at least one active site to the at least one generation polymer end of the macromolecule,
- (5) bonding at least one further generation polymer to the at least one active site of the macromolecule to provide an active site on the macromolecule, and
- (6) repeating steps (4) and (5) until a predetermined number of generation polymers have been added, and
- (b) bonding a multifunctional group having two or more active sites to the non-functionalised end of the first polymer and bonding two or more dendrons to the active sites of the multifunctional group bonded to the first polymer.
A method of forming a dendritic molecule comprising the steps of:
- forming a first polymer comprising two or more functional groups having at least one active site;
- bonding two or more first generation polymers with the active sites to form a first generation macromolecule thereby forming a first generation macromolecule wherein the first generation polymer comprises two or more functional groups having at least one active site;
- and
- iteratively bonding further generation polymers to the active site on the first generation macromolecule, each iterative step resulting in a generation macromolecule having a functional group with an active site until termination.
A method of divergently forming a dendritic molecule comprising the steps of:
- (a) forming a first polymer
- (b) bonding two or more functional groups having at least one active site to the first polymer;
- (c) bonding two or more generation polymers to the active sites on the first polymer to form a first generation macromolecule;
- (d) bonding one or more functional groups having at least one active site to a plurality of sites on the first generation macromolecule;
- (e) repeating steps (c) and (d) until a predetermined number of generation polymers have been added.
A method of forming a dendritic molecule comprising the steps of forming a star polymer each of whose arms comprises a functional group having an active site and bonding one or more dendrons to the active site.
Dependencies are inferred from the claim text.