Differentiation therapy for sarcomas
OwnerCarola Ponzetto, Riccardo Taulliinventors
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Abstract
Use of muscle-enriched/specific microRNAs for the treatment of sarcomas, as for example rhabdomyosarcomas, synovial sarcoma, alveolar soft part sarcoma, liposarcoma, and osteosarcoma, wherein the microRNAs are able to stop the development of neoplastic cells and to force the neoplastic cells to differentiate into terminally differentiated muscle cells.
Claims8
microRNA for use in differentiation treatment of sarcoma for converting said sarcoma cells into terminally differentiated myogenic cells, wherein said microRNA is a muscle-enriched/specific microRNA, and wherein said muscle-enriched/specific microRNA is selected among microRNA-1, microRNA-206 and combinations thereof.
Dependencies are inferred from the claim text.