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US 2012/0059149 A1Published application
Branched chain-containing aromatic compound
AssigneeAjinomoto Co., Inc.
InventorDaisuke TAKAHASHI
Life of this patent
Estimating the term…
Abstract
[Summary] [Problem] Provision of a novel compound which is easily-soluble in isopropyl acetate superior in liquid-separation operability, and can be used for a production method of peptide and the like, that provides a final product simply by extraction-layer-separating, without crystallization and isolation of each intermediate in each step. [Solving Means] It has been found that the above-mentioned problems can be solved by a particular branched chain-containing aromatic compound.
Claims24
A branched chain-containing aromatic compound represented by the general formula (I):
- wherein
- Q in the number of k are a single bond, or O, S, CO2, CONH or NH;
- Ra in the number of k are each independently an organic group having at least one aliphatic hydrocarbon group having one or more branched chains, a total number of the branched chain of not less than 3 and a total carbon number of not less than 14 and not more than 300;
- k is an integer of 1-4;
- R1 is a hydrogen atom or, when Z is a group represented by the following formula (a), it optionally shows a single bond together with R2 to form a fluorene ring together with ring B;
- ring A optionally further has, in addition to R1, QRa in the number of k, and C(X)(Y)Z, substituent(s) selected from the group consisting of a halogen atom, a C1-6 alkyl group optionally substituted by one or more halogen atoms, and a C1-6 alkoxy group optionally substituted by one or more halogen atoms;
- X is a hydrogen atom or a phenyl group;
- Y is a hydroxyl group or an —NHR group (R is a hydrogen atom, an alkyl group or an aralkyl group);
- and
- Z is a hydrogen atom or a group represented by the formula (a):
- wherein * shows a bonding position;
- m is an integer of 0-4;
- Q in the number of m are as defined above;
- Rb in the number of m are each independently an organic group having at least one aliphatic hydrocarbon group having one or more branched chains, a total number of the branched chain of not less than 3 and a total carbon number of not less than 14 and not more than 300;
- R2 is a hydrogen atom, or optionally shows a single bond together with R1 to form a fluorene ring together with ring A;
- and
- ring B optionally further has, in addition to QRb in the number of m, and R2, substituent(s) selected from the group consisting of a halogen atom, a C1-6 alkyl group optionally substituted by one or more halogen atoms, and a C1-6 alkoxy group optionally substituted by one or more halogen atoms);
- the organic group having at least one aliphatic hydrocarbon group having one or more branched chains, a total number of the branched chain of not less than 3 and a total carbon number of not less than 14 and not more than 300 for the above-mentioned Ra and Rb is a group having 3 or more the same or different divalent groups, which is represented by the formula (b):
- wherein * shows a bonding position with the adjacent atom;
- R3 and R4 are each independently a hydrogen atom or a C1-4 alkyl group;
- X1 is a single bond, a C1-4 alkylene group or an oxygen atom,
- provided that R3 and R4 are not hydrogen atoms at the same time.
19 more elements
Dependencies are inferred from the claim text.