Non-naturally occurring lipoprotein particle

A non-naturally occurring, receptor competent low density lipoprotein particle comprising at least one peptide component wherein the peptide component is covalently bonded at the amino and/or carboxy terminus thereof to at least one lipophilic substituent, wherein the at least one peptide component comprises at least a binding site for an Apo B protein receptor, wherein the binding sequence of the peptide component has an amino acid sequence selected from the group consisting of (1) Lys Ala Glu Tyr Lys Lys Asn Lys His Arg His (SEQ ID NO:

• 1);
• (2) Thr Thr Arg Leu Thr Arg Lys Arg Gly Leu Lys (SEQ ID NO:
• 2);
• and (3) Arg Leu Thr Arg Lys Arg Gly Leu Lys (SEQ ID NO:
• 8), and wherein the at least one peptide component is from 8 to 500 amino acid residues long.