Method for site-selectively cleaving target nucleic acid
AssigneeThe University of Tokyo
InventorsMakoto Komiyama, Tuomas Lonnberg, Yuta Suzuki
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Abstract
There is provided a method for cleaving a target nucleic acid at a desired site using a metal ion or a metal ion complex as a catalyst for cleaving a nucleic acid (DNA, etc.), which has high site-selectivity, high reaction efficiency and low side-reactivity (non-specific reactivity), and is economical and convenient. The method for cleaving a target nucleic acid of the present invention comprises allowing a target nucleic acid to come into contact with a specific complex compound and a metal ion or a metal complex, or allowing a target nucleic acid to come into contact with a specific complex compound, to which a metal ion or a metal complex binds.
Claims33
A complex compound, wherein a compound containing multiple phosphono groups binds to a compound binding to a specific nucleic acid sequence via a linker portion containing an O-alkyloxime group.
Dependencies are inferred from the claim text.