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US 2012/0059131 A1Published application
Ph sensitive graft copolymer
AssigneeCouncil of Scientific and Industrial Research
InventorsRamesh Muthusamy, Mohan Gopalkrishna Kulkarni
Life of this patent
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Abstract
Graft copolymer (P) which exhibit pH dependent swelling/dissolution properties comprising a hydrophobic back-bone and graft chains comprising acidic monomer. This Graft copolymer (P) do not swell or dissolve at acidic pH prevalent in the stomach and they swell/dissolve at near neutral pH prevalent in the intestinal region. The graft copolymer (P) is useful for the development of drug delivery formulations particularly for oral drug delivery formulations.
Claims16
A graft copolymer (P) of formula 1 which exhibits pH dependent behavior
- comprises:
- a. a backbone having the formula P [A(x) B(y) C(z)] comprising a diol (A), a dicarboxylic acid or acid anhydride (B) and a monomer containing pendent unsaturation (C) wherein (x)=37-46%, (y)=49-55% (z)=5-8% by mole;
- and
- b. a graft which is a polymer of the acidic monomer (D) and ‘w’ is weight percent of the total weight of the said graft copolymer such that ‘w’ is 22-56%.
1 more element
Dependencies are inferred from the claim text.