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US 2012/0059111 A1Published application
Lubricious coatings for medical devices
AssigneeBioInteractions Ltd.
InventorsShivpal S. Sandhu, Alan Rhodes, Simon Jon Onis
Life of this patent
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Abstract
Substrates may be coated with copolymers of N-vinyl pyrrolidinone and aryl ketones. Processes are described for making the copolymers at high molecular weight with the ketones randomly dispersed on the copolymer.
Claims24
A coating on a medical device comprising
- a hydrophilic layer comprising copolymers covalently crosslinked by photoinitiation of diaryl ketones pendant on the copolymers,
- with the copolymers, before photoinitiation, being polymerized from a plurality of monomers comprising N-vinyl pyrrolidinone and diaryl ketone vinyl monomer, having a weight average molecular weight of more than about 100,000, at least about 60% by weight N-vinyl pyrrolidinone, no more than about 5% by weight of diaryl ketone monomer that provides the pendant diaryl ketones, and a random distribution of the diaryl ketones.
An isolated set of polymers comprising
- copolymers polymerized from monomers comprising N-vinyl pyrrolidinone monomer and a diaryl ketone vinyl monomer,
- with the copolymers having a weight average molecular weight of more than about 100,000, at least about 60% by weight N-vinyl pyrrolidinone, no more than about 5% by weight diaryl ketone monomer, and a random distribution of the diaryl ketone in the copolymer.
A method of coating a medical device comprising
- exposing a medical device to
- copolymers having a weight average molecular weight of more than about 100,000, at least about 60% by weight N-vinyl pyrrolidinone, diaryl ketone monomer present at no more than about 5% by weight, and a random distribution of the diaryl ketone in the copolymer, and
- an ultraviolet source to activate the benzophenone to form crosslinks to create a covalently crosslinked layer on a surface of the medical device.
A process of making a copolymer comprising
- preparing a solution of N-vinyl pyrrolidinone in aqueous solution,
- adding a free radical polymerization initiator dissolved in N-vinyl pyrrolidinone to the solution,
- adding a aryl ketone vinyl monomer dissolved in N-vinyl pyrrolidinone to the solution,
- and polymerizing the monomers to form a random copolymer of the N-vinyl pyrrolidinone and the diaryl ketone monomer.
1 more element
Dependencies are inferred from the claim text.