Tamper Resistant Dosage Form Comprising An Anionic Polymer
AssigneeGrüNenthal GmbH
InventorsLutz Barnscheid, Sebastian Schwier, Johannes Bartholomäus
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Abstract
A pharmaceutical dosage form and method of using same, the pharmaceutical dosage form exhibiting a breaking strength of at least 500 N, said dosage form containing a pharmacologically active ingredient (A); an anionic polysaccharide (B) obtainable by introducing anionic functional groups, in protonated form or a physiologically acceptable salt thereof, into a polysaccharide; and a polyalkylene oxide (C); wherein the pharmacologically active ingredient (A) is present in a controlled-release matrix comprising the anionic polysaccharide (B) and the polyalkylene oxide (C).
Claims14
A pharmaceutical dosage form exhibiting a breaking strength of at least 500 N, said dosage form comprising:
- a pharmacologically active ingredient (A);
- an anionic polysaccharide (B) obtainable by introducing anionic functional groups, in protonated form or a physiologically acceptable salt thereof, into a polysaccharide;
- and
- a polyalkylene oxide (C);
- wherein the pharmacologically active ingredient (A) is present in a controlled-release matrix comprising the anionic polysaccharide (B) and the polyalkylene oxide (C).
Dependencies are inferred from the claim text.