Garcinia derivative, its preparing method and medicinal use
AssigneeChina Pharmaceutical University
InventorsQidong You, Xiaojian Wang, Qian Yang, Na Lu, Changjun Lin, Qinglong Guo
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Abstract
The present invention relates to a field of pharmaceutical chemistry, more specifically, the present invention relates to a garcinia derivative Formula (I), its preparing method, and medicinal use. Wherein the definitions of R1 and R2 are disclosed in the specification of the present invention, and the derivative of the present invention is a structurally simplified analogue of the gambogic acid compound; wherein the gambogic acid compound possesses anti-cancer characteristics, and could be used for preparation of anti-tumor drugs.
Claims7
A compound of Formula (I) or its pharmaceutically acceptable salt:
- Wherein R1 is a single substituted or a multi substituted group;
- when R1 is the single substituted group, R1 is a hydroxyl group;
- and when R1 is the multi substituted group, one of the substituted groups is a hydroxyl group, and the rest of substituted groups are selected from an amino group, a hydroxyl group, a nitro group, a cyano group, an alkyl group containing C1-C6 carbons, or an alkenyl group containing C2-C6 carbons;
- wherein R2 is hydrogen, halogen, a hydroxyl group, an alkoxy group containing C1-C4 carbons, an amide group containing C1-C4 carbons, a carboxyl group, or an aldehyde group.
Dependencies are inferred from the claim text.