Methods of utilizing the arrestin-2/stam-1 complex as a therapeutic target
AssigneeLoyola University of Chicago
InventorsAdriano Marchese, Rohit Malik
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Abstract
Methods of utilizing the arrestin-2/sTAM-1 complex as a therapeutic target. The methods include treating cells of a living organism to mediate an interaction between arrestin-2 and STAM-1 adapter protein molecules, wherein the interaction is characterized by the arrestin-2 adapter protein molecule directly binding to the STAM-2 adapter protein molecule. Pharmacological agents can be identified for therapeutic uses by determining whether the pharmacological agent disrupts the interaction between the arrestin-2 and STAM-1 adapter protein molecules.
Claims30
A method of modulating endosomal sorting of the CXC chemokine receptor 4 (CXCR4) in cells of a living organism, the method comprising treating cells of the living organism to mediate an interaction between an arrestin-2 adapter protein molecule and a STAM-1 adapter protein molecule, wherein the interaction is characterized by the arrestin-2 adapter protein molecule directly binding to the STAM-1 adapter protein molecule.
A method of identifying a pharmacological agent to treat metastasis of a cancer in living organisms, the method comprising:
- treating cells of a living organism with the pharmacological agent;
- and
- determining whether the pharmacological agent disrupts an interaction between an arrestin-2 adapter protein molecule and a STAM-1 adapter protein molecule of cells of the living organism, wherein the interaction is characterized by the arrestin-2 adapter protein molecule directly binding to the STAM-2 adapter protein molecule.
Dependencies are inferred from the claim text.