Therapeutic and diagnostic strategies
AssigneeImmune Disease Institute, Inc.
InventorsJudy Lieberman, Ashish Lal, Dipanjan Chowdhury
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Abstract
The present invention encompasses the finding that microRNAs (miRNAs) regulate certain key proteins involved in DNA repair. In some embodiments, a miRNA suppresses levels and/or activity of one or more DNA repair proteins. In some such embodiments, such suppression renders cells hypersensitive to certain DNA damage agents (e.g., γ-irradiation and genotoxic drugs, among others). The present invention provides various reagents and methods associated with these findings including, among other things, strategies for treating cell proliferative disorders, certain diagnostic systems, etc.
Claims12
A method comprising steps of:
- administering to an individual who is suffering from or susceptible to a cell proliferative disorder a composition comprising an miRNA agent in an amount sufficient to inhibit cell proliferation.
A method comprising steps of:
- administering to an individual who is suffering from or susceptible to a cell proliferative disorder a composition comprising an miRNA agent in an amount sufficient to render cells of the individual hypersensitive to DNA damage agents.
A method comprising steps of:
- antagonizing an miRNA agent in a cell, such that cell proliferation is increased.
Dependencies are inferred from the claim text.