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US 2012/0059041 A1Published application
Methods for Extending Lifespan in Subject
AssigneeNational Tsing Hua University
InventorsHorng-Dar WANG, Chiou-Hwa YUH, Wan-Chih LU
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AssigneeNational Tsing Hua University
InventorsHorng-Dar WANG, Chiou-Hwa YUH, Wan-Chih LU
Estimating the term…
Disclosed is a method for extending lifespan in a subject. By screening for mutations that enhance resistance to multiple stresses, the invention identified multiple alleles of alpha-1, 2-mannosidase I (mas1) which, in addition to promoting stress resistance, also extended longevity. Meanwhile, longevity enhancement of a subject is also observed when either the expression of mas1 or its downstream gene Edm1 is reduced. Furthermore, this invention also found that the down-regulating mas1 and Edm1 may extend longevity by modulating DR (Dietary Restriction). Thus, via molecular biology techniques, the expression of the target genes such as mas1 and Edm1 can be regulated, and the lifespan extension for a subject also can be achieved.
A method for extending lifespan in a subject, comprising the step of altering the protein expression level of at least one multiple stress activating protein to extend the lifespan in the subject, wherein the multiple stress activating protein is selected from the group consisting of alpha-1,2-mannosidase I (mas1) and ER degradation-enhancing alpha-1,2-mannosidase-like protein (Edm1).
A DNA fragment for regulating mas1 gene expression, having a nucleotide sequence of SEQ ID NO:
Dependencies are inferred from the claim text.