Substituted pyridine derivatives and their medical use

A compound of Formula (I)

• a stereoisomer or a mixture of its stereoisomers, or a pharmaceutically acceptable addition salt thereof, or an N-oxide thereof, wherein
• R1 and R2, independently of each other, represent hydrogen, C1-6-alkyl, hydroxy-C1-6-alkyl or C1-6-alkoxy-C1-6-alkyl;
• or
• R1 and R2, together with the nitrogen to which they are attached, form a heterocyclic ring selected from pyrrolidinyl, 2,5-dihydro-1H-pyrrol-1-yl, thiazolidinyl, piperidinyl, piperazinyl and morpholinyl, which pyrrolidinyl, piperidinyl, piperazinyl and morpholinyl is optionally substituted one or more times with a substituent selected from the group consisting of halogen, hydroxy, amino, C1-6-alkyl, trifluoromethyl, C1-6-alkoxy, hydroxy-C1-6-alkyl and C1-6-alkoxy-C1-6-alkyl;
• L represents a linker selected from —CR′R″—, —CH2—CR′R″— and —CR′R″—CH2—, wherein R′ and R″, independently of each other, represent hydrogen, C1-6-alkyl or halogen;
• n is 0, 1;
• R3 represents C1-6-alkyl, phenyl or furanyl, which phenyl and furanyl is optionally substituted one or more times with substituents selected from C1-6-alkyl, C1-6-alkoxy, halogen and trifluoromethyl;
• and
• R4 represents hydrogen, halogen or C1-6-alkyl.