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US 2012/0059032 A1Published application
1,2,3,4-tetrahydroisoquinoline derivatives effective as antiglioma agents, methods of making, and their use
AssigneeUniversity of Tennessee Research Foundation
InventorsRenukadevi Patil, Shivaputra A. Patil, Duane D. Miller, Charles Ryan Yates, Eldon E. Geisert
Life of this patent
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Abstract
Disclosed are tetrahydroisoquinoline-derivative compounds effective for killing cancer cells, shrinking tumor size, and treating cancer.
Claims10
A compound of Formula (I)
- where R1 is
- R2 is —OCH3, —CF3, —NHSO2CH3, —NHCOCH3, —SO2CH3, —N(CH3)2, —CN, —NO2, —NH2, —CO2CH3, —OCF3, —CH3, —F, —Br, or —I;
- R3 is —OCH3;
- and
- R4 and R5 are —H or —OCH3, wherein when R4 is —H, R5 is —OCH3 and when R4 is —OCH3, R5 is —H.
2 more elements
A method comprising administering a compound of Formula (I) to a patient to kill cancer cells, reduce tumor size, and treat cancer,
- wherein R1 is
- R2 is —OCH3, —CF3, —NHSO2CH3, —NHCOCH3, —SO2CH3, —N(CH3)2, —CN, —NO2, —NH2, —CO2CH3, —OCF3, —CH3, —F, —Br, or —I;
- R3 is —OCH3;
- and
- R4 and R5 are —H or —OCH3, wherein when R4 is —H, R5 is —OCH3 and when R4 is —OCH3, R5 is —H.
2 more elements
Dependencies are inferred from the claim text.