Chemical compounds, compositions and methods for kinase modulation

A compound of formula (Ib):

• or pharmaceutically acceptable forms thereof, wherein
• B is hydrogen, alkyl, amino, heteroalkyl, or a moiety of Formula II:
• wherein Wc is aryl, heteroaryl, heterocycloalkyl, or cycloalkyl;
• q is an integer of 0, 1, 2, 3, or 4;
• X is absent or —(CH(R9))z—, and z is an integer of 1, 2, 3, or 4;
• Y is absent, —O—, —S—, —S(═O)—, —S(═O)2, —C(═O)—, —C(═O)(CHR9)z—, —N(R9)—, N(R9)—C(═O)—, —N(R9)—C(═O)NH—, or —N(R9)C(R9)2—, and z is an integer of 1, 2, 3, or 4;
• R1 is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, amido, alkoxycarbonyl, sulfonamido, halo, cyano, or nitro;
• each R2 is independently alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, alkoxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, cyano, hydroxy, nitro, phosphate, urea, or carbonate;
• R3 is cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocyclyl, aralkyl, heteroaralkyl, heterocyclylalkyl, alkenyl, or alkynyl, or R3 is a heteroatom selected from N, S, and O, wherein the heteroatom has a covalent bond either directly or through a C1-C6 alkyl group to an aryl, heteroaryl or heterocyclyl, or R3 and R5 are taken together with the carbons to which they are attached form a 5- or 6-membered ring;
• wherein each of the above substituents can be substituted with 0, 1, 2, or 3 R13;
• R5, R6, R7, and R8 are independently hydrogen, halo, cyano, alkyl or amino;
• each R9 is independently hydrogen, alkyl, or heterocycloalkyl;
• Wd is
• R11 is hydrogen, alkyl, halo, amino, amido, hydroxy, alkoxy, phosphate, urea, or carbonate;
• R12 is hydrogen, alkyl, haloalkyl, alkynyl, alkenyl, halo, —C(O)NH2, aryl, heteroaryl, nonaromatic heterocyclyl, or cycloalkyl,
• Ra′ is hydrogen, alkyl, —NH2, cyano or halogen;
• and
• each R13 is independently hydrogen, C1-C6 alkyl, C1-C6 alkoxy or halogen.