Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
AssigneeSuperGen, Inc.
InventorsYong Xu, Benjamin G. Brenning, Steven G. Kultgen, Xiaohui Liu, Michael Saunders, Koc-Kan Ho
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Abstract
The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II): or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.
Claims14
A compound having a structure according to structure (I) or structure (II) below:
- or a stereoisomer or pharmaceutically acceptable salt thereof,
- wherein:
- X is a direct bond, NH, N(alkyl), S, O, SO or SO2;
- R is H, —OH, halo, alkyl, haloalkyl, alkoxy or haloalkoxy;
- R1 is phenyl or substituted phenyl;
- and
- R2 is —(CH2)n-cyclobutyl, —(CH2)-piperidin-2-onyl, —(CH2)n-thiomorpholinylsulfone, —(CH2)n-phenyl, —(CH2)n-tetrahydropyranyl, —(CH2)n-tetrahydrothiopyranyl, —(CH2)n-tetrahydrothiopyranylsulfone or —(CH2)nCH(CH3)2OH, where n is 0, 1, 2, 3 or 4 and each of the above moieties are optionally substituted with one or more substituents;
- or R2 is selected from:
A compound having a structure selected from:
A compound having a structure selected from:
A compound having a structure selected from:
Dependencies are inferred from the claim text.