Carbazole carboxamide compounds useful as kinase inhibitors

A compound according to formula (I):

• or a salt thereof, wherein
• the dashed lines are either single or double bonds;
• A is halo, C3-10 carbocycle substituted with 0-3 B, C6-10 mono- or bicyclic aryl substituted with 0-3 B, a 5-14 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 B, a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 B;
• B is R1, halogen, cyano, nitro, —O—R1, —C(═O)—R1, —C(═O)O—R1, —C(═O)NR11—R1, —S(═O)2—R1, —NR11C(═O)—R1, —NR11C(═O)NR11—R1, —NR11C(═O)O—R1, —N(C(═O)O—R1)2, —NR11S(═O)2—R1, —N(S(═O)2—R1)2, or —NR11—R1;
• R1 is hydrogen, C1-6 alkyl substituted with 0-3 R1a, C1-6 haloalkyl, C2-6 alkenyl substituted with 0-3 R1a, C2-6 alkynyl substituted with 0-3 R1a, C3-10 cycloalkyl substituted with 0-3 R1a, C6-10 aryl substituted with 0-3 R1a, a 5-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R1a, a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R1a;
• R1a is hydrogen, C═O, F, Cl, Br, OCF3, CF3, CHF2, CN, NO2, —(CH2)rORb, —(CH2)rSRb, —(CH2)rC(O)Rb, —(CH2)rC(O)ORb, —(CH2)rOC(O)Rb, —(CH2)rNR11R11, —(CH2)rC(O)NR11R11, —(CH2)rNRbC(O)Rc, —(CH2)rNRbC(O)ORc, —NRbC(O)NR11R11, —S(O)pNR11R11, —NRbS(O)pRc, —S(O)Rc, —S(O)2Rc, C1-6 alkyl substituted with 0-2 Ra, C1-6 haloalkyl, —(CH2)r-3-14 membered carbocycle substituted with 0-1 Ra, or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-1 Ra;
• one of D1 and D2 is D and the other is H or halo;
• D is —R2, halogen, —(C(R11)2)r—R2, —O—R2, —C(═O)—R2, —C(═O)O—R2, —C(═O)NR11—R2, —S(═O)2—R2, —S(═O)—R2, —NR11C(═O)—R2, —NR11C(═O)NR11—R2, —NR11C(═O)O—R2, —NR11S(═O)2—R2, —NR11—R2, —C(═O)NR11—O—R2, —OC(═O)O—R2, —O1C(═O)—R2, or CH═N—OH;
• with the proviso that A is not halo when D is —C(═O)O—R2,
• R2 is hydrogen, C1-6 alkyl substituted with 0-3 R2a, C2-6 alkenyl substituted with 0-3 R2a, C2-6 alkynyl substituted with 0-3 R2a, C3-10 cycloalkyl substituted with 0-3 R2a, C6-10 aryl substituted with 0-3 R2a, a 5-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R2a, a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R2a;
• R2a is hydrogen, C═O, F, Cl, Br, OCF3, CN, NO2, —(CH2)rORb, —(CH2)rSRb, —(CH2)rC(O)Rb, —(CH2)rC(O)ORb, —(CH2)rOC(O)Rb, —(CH2)rNR11R11, —(CH2)rC(O)NR11R11, (CH2)rNRbC(O)Rc, —(CH2)rNRbC(O)ORc, —NRbC(O)NR11R11, —S(O)pNR11R11, —NRbS(O)pRc, —S(O)Rc, —S(O)2Rc, C1-6 alkyl substituted with 0-2 Ra, C1-6 haloalkyl, —(CH2)r-3-14 membered carbocycle substituted with 0-1 Ra, or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-2 Ra;
• R11 is independently hydrogen or C1-4 alkyl substituted with 0-1 Rf, CH2-phenyl, or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p;
• alternatively, R11 and along with another R11, R1, or R2 on the same nitrogen atom may join to form an azetidinyl, pyrrolidinyl, piperidinyl, morpholinyl, or 4-(C1-6 alkyl)piperazinyl;
• Ra is hydrogen, F, Cl, Br, OCF3, CF3, CHF2, CN, NO2, —(CH2)rORb, —(CH2)rSRb, —(CH2)rC(O)Rb, —(CH2)rC(O)ORb, —(CH2)rOC(O)Rb, —(CH2)rNR11R11, —(CH2)rC(O)NR11R11, —(CH2)rNRbC(O)Rc, —(CH2)rNRbC(O)ORc, —NRbC(O)NR11R11, —S(O)pNR11R11, —NRbS(O)pRc, —S(O)Rc, —S(O)2Rc, C1-6 alkyl substituted with 0-1 Rf, C1-6 haloalkyl, —(CH2)r-3-14 membered carbocycle, or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, alternatively two Ra on adjacent or the same carbon atom form a cyclic acetal of the formula —O—(CH2)n—O—, or —O—CF2—O—, wherein n is selected from 1 or 2;
• Rb is hydrogen, C1-6 alkyl substituted with 0-2 Rd, C1-6 haloalkyl, C3-6 cycloalkyl substituted with 0-2 Rd, or (CH2)r-phenyl substituted with 0-2 Rd;
• Rc is C1-6 alkyl substituted with 0-1 Rf, C3-6 cycloalkyl, or (CH2)r-phenyl substituted with 0-1 Rf;
• Rd is hydrogen, F, Cl, Br, OCF3, CF3, CN, NO2, —ORe, —(CH2)rC(O)Rc, —NReRe, —NReC(O)ORc, C1-6 alkyl, or (CH2)r-phenyl;
• Re is hydrogen, C1-6 alkyl, C3-6 cycloalkyl, or (CH2)r-phenyl;
• Rf is hydrogen, halo, NH2, OH, or OCH3;
• r is 0, 1, 2, 3, or 4;
• and
• p is 0, 1, or 2.