Therapeutic approaches for treating alzheimer disease and related disorders through a modulation of angiogenesis
AssigneePharnext
InventorsDaniel Cohen, Ilya Chumakov, Serguei Nabirochkin, Oxana Guerassimenko, Esther Graudens
Life of this patent
Estimating the term…
Abstract
The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate angiogenesis for treating said disease.
Claims12
A composition comprising baclofen or terbinafine, or a salt, prodrug, derivative, or sustained release formulation thereof, for treating Alzheimer's disease (AD) in a subject in need thereof.
A composition comprising at least one of the following drug combinations, or salts or prodrugs or derivatives or sustained release formulations thereof, the drugs in each of said combinations being for simultaneous, separate or sequential administration:
- baclofen and sulfisoxazole,
- baclofen and leflunomide,
- terbinafine and sulfisoxazole,
- terbinafine and leflunomide,
- terbinafine and fenoldopam,
- terbinafine and mepacrine,
- terbinafine and phenformin,
- terbinafine and clopidogrel,
- baclofen and phenformin,
- terbinafine and levosimendan,
- baclofen and clopidogrel, or
- baclofen and levosimendan.
A method of producing a drug for treating Alzheimer's disease, the method comprising a step of testing a candidate drug for activity on angiogenesis and selecting candidate drugs which increase angiogenesis.
A method of treating Alzheimer's disease, the method comprising administering to a subject in need thereof, an effective amount of baclofen or terbinafine, or a salt, prodrug, derivative, or sustained release formulation thereof.
Dependencies are inferred from the claim text.