Antibacterial fluoroquinolone analogs

A compound having the following structure (I):

• or a stereoisomer, pharmaceutically acceptable salt or prodrug thereof,
• wherein:
• A, B and D are as follows:
• A is —C(R8b)2—, —C(═O)—, —C(R8b)(OR8a)—, —C(R8b)(N(R8a)2)—, —C(═NOR8a)—, —S(═O)— or —SO2—;
• B is —C(R8b)2—, —C(═O)—, —C(R8b)(OR8a)—, —C(R8b)(N(R8a)2)—, —C(═NOR8a)—, —O—, —S—, —S(═O)—, —SO2— or —N(R8a)—;
• and
• D is —C(R8b)2—, —C(═O)—, —O—, —S—, —S(═O)—, —SO2—, —N(R8a)—, —C(R8b)(OR8a)— or —C(R8b)(N(R8a)2)—;
• or taken together, are —C(R8b)═C(R8b)—, —C(R8b)═N— or
• or
• or B-D, taken together, are —C(R8b)═C(R8b)—, —N═C(R8b)— or
• E is —C(R8c)2— or —C(═O)—;
• G is hydrogen or methyl;
• R1 is optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl;
• R2 is hydrogen, methyl or amino;
• R3 is hydrogen, fluorine or chlorine;
• R4, R5, R6, R7 are, independently, hydrogen, halogen, amino, hydroxyl, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkoxy, optionally substituted alkylamino or —N(R8a)2, or R4 and R5, taken together, are ═CHR8b, ═NOR8a, ═NNR8a or ═O or, together with the atom to which they are attached, form an optionally substituted heterocyclic ring having from 3 to 6 ring atoms, or R6 and R7, taken together, are ═CHR8b, ═NOR8a, ═NNR8a or ═O, or, together with the atom to which they are attached, form an optionally substituted heterocyclic ring having from 3 to 6 ring atoms, or R5 and R6, R5 and R7, R4 and R6, or R4 and R7, taken together with the atoms to which they are attached, form a heterocyclic ring having from 3 to 6 ring atoms;
• each R8a is, independently, hydrogen, C1-C6 alkyl, C1-C6 cycloalkyl, C1-C6 cycloalkylalkyl or —C(═O)R8c;
• each R8b is, independently, hydrogen, halogen, C1-C6 alkyl, C1-C6 cycloalkyl, C1-C6 haloalkyl or C1-C6 cycloalkylalkyl;
• and
• each R8c is, independently, hydrogen or C1-C6 alkyl.