Therapeutic uses of quinazolinedione derivatives

A compound corresponding to the general formula (I)

• in which
• A represents an aryl group or a heteroaryl group;
• R1 represents:
• a hydrogen atom,
• —C(O)R in which R is a hydrogen atom, a (C1-C6)alkoxy group, an aryl group, a (C3-C6)cycloalkyl group or a (C1-C6)alkyl group, the said alkyl optionally being substituted by:
• one or more hydroxyl group(s),
• a benzyloxy group,
• a (C1-C6)alkoxy group, optionally substituted by an aryl, or
• a (C3-C6)cycloalkyl group,
• an optionally substituted (C1-C6)alkyl group;
• R2 represents:
• a hydrogen atom,
• a halogen atom,
• a cyano group,
• a nitro group,
• a (C1-C6)alkyl group optionally substituted by an —NH2 or else by an —NHC(O)Rb group, with Rb as defined below,
• an —ORa group in which Ra represents:
• a hydrogen atom,
• a (C1-C6)alkyl group optionally substituted by one or more halogen atom(s), by one or more hydroxyl group(s), by an aryl group and/or by one or more cyano group(s),
• a (C2-C6)alkynyl group,
• an aryl group;
• R3 represents:
• a hydrogen atom,
• a halogen atom,
• a hydroxyl group,
• a cyano group,
• an —SCF3 group,
• a nitro group,
• an oxo group,
• an —S(O)0-2-alkyl group, an —S(O)0-2-heterocycloalkyl group, an —O—SO2-aryl group optionally substituted by one or more halogen atom(s);
• an -alkylaminoalkyl or -cycloalkylaminoalkyl group, each optionally substituted on the end alkyl,
• an optionally substituted sulphonamide group,
• an aryl group or a heteroaryl group, the said group being monocyclic or polycyclic and in addition optionally being substituted by a (C1-C6)alkyl group, by one or more halogen atom(s) or by a (C1-C6)alkoxy group,
• a heterocycloalkyl group optionally substituted by a (C1-C6)alkyl group,
• a (C1-C6)alkyl group optionally substituted by:
• one or more halogen atom(s),
• an aryl group which can be substituted by one or more halogen atom(s) or by one or more hydroxyl group(s),
• a heteroaryl group,
• one or more hydroxyl group(s) which can be substituted by an aryl group itself optionally substituted by one or more halogen atom(s), or
• a heterocycloalkyl group optionally substituted by a CO(O)Ra group or by a (C1-C6)alkyl group, with Ra as defined above,
• a —C(O)NRbRc group, with Rb and Rc as defined below,
• a —C(O)ORc group or an —O—C(O)ORc group, with Rc as defined below,
• a (C1-C6)alkoxy group, optionally substituted by
• an aminoalkyl group,
• an aminocycloalkyl group,
• a cycloalkyl group,
• a heterocycloalkyl group,
• a monocyclic or polycyclic heteroaryl group,
• one or more hydroxyl group(s),
• one or more halogen atom(s),
• a (C1-C6)alkoxy group,
• a —C(O)ORc group, with Rc as defined below,
• a —C(O)NRbRc group, with Rb and Rc as defined below,
• an oxo group, and/or
• an aryl group, itself optionally substituted by one or more halogen atom(s), a cyano group, a (C1-C6)alkoxy group, an —O-haloalkyl group and/or a haloalkyl group,
• an —O-cycloalkyl group, an —O-aryl group or an —O-heterocycloalkyl group, each optionally substituted by
• an aryl group, itself optionally substituted by one or more halogen atom(s) or by a (C1-C6)alkyl group,
• an oxo group,
• one or more halogen atom(s), and/or
• a (C1-C6)alkyl group, which can itself be substituted by an aryl group and/or an oxo group,
• an —NH—CO—NH-aryl group, an —NH—CO—NH-heteroaryl group or an —NH—CO—NH—(C1-C6)alkyl group, each optionally being substituted by one or more halogen atom(s), by a cyano group, by a nitro group, by one or more hydroxyl group(s) or by a (C1-C6)alkoxy group,
• an —N—(C1-C6)alkyl group, it being possible for the (C1-C6)alkyl group to be substituted by
• one or more oxo group(s), and/or
• one or more aryl group(s) optionally substituted by one or more halogen atom(s) and/or by an SO2 group,
• an —NH—CO-aryl group or an —NH—CO-heteroaryl group, each optionally being substituted by one or more halogen atom(s);
• or else R3 forms, with A, a polycyclic heteroaryl group optionally substituted by a (C1-C6)alkoxy group or a (C1-C6)alkyl group optionally substituted by an aryl group which can itself be substituted by one or more halogen atom(s);
• R4 represents a hydrogen atom, an oxo group or a (C1-C6)alkyl group;
• Rb represents:
• a hydrogen atom,
• a (C1-C6)alkyl group optionally substituted by one or more halogen atom(s), by one or more hydroxyl, cyano, amino, heterocycloalkyl or (C1-C6)alkoxy group(s) or by an aryl group optionally substituted by one or more halogen atom(s),
• a (C3-C6)cycloalkyl group,
• a (C2-C6)alkynyl group,
• a (C1-C6)alkoxy group,
• an aryl group optionally substituted by one or more halogen atom(s);
• Rc represents a hydrogen atom or a (C1-C6)alkyl group optionally substituted by one or more halogen atom(s);
• or then Rb and Rc form, together with the nitrogen atom to which they are attached, a polycyclic heteroaryl group or a heterocycloalkyl group;
• m and n represent, independently of one another, the value 0, 1 or 2, it being understood that m+n≦3;
• p and p′ represent, independently of one another, the value 1, 2 or 3, it being understood that, when p is greater than or equal to 2, then the R2 groups are on separate carbon atoms and can be different from one another and, when p′ is greater than or equal to 2, then the R3 groups are on separate carbon atoms and can be different from one another;
• q represents the value 0 or 2, it being understood that, when q=0, then the nitrogenous heterocyclic group attached to the nitrogen situated in the 1 position of the 2,4-dioxo-1,2,3,4-tetrahydroquinazoline ring system is no longer bridged and is of the type:
• with R1, R4, m and n as defined above,
• r represents the value 0 or 1;
• in the form of the base or of an addition salt with an acid.