Analogs of Benzoquinone-Containing Ansamycins and Methods of Use Thereof
AssigneeInfinity Pharmaceuticals, Inc.
InventorsJulian Adams, Yun Gao, Asimina T. Georges Evangelinos, Louis Grenier, Roger H. Pak, James R. Porter, James L. Wright
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Abstract
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
Claims13
1-151. (canceled)
A pharmaceutical composition, comprising an antioxidant;
- a metal chelator;
- and a salt represented by formula I:
- wherein
- said antioxidant is ascorbic acid;
- and
- said metal chelator is ethylenediamine tetraacetic acid (EDTA).
Dependencies are inferred from the claim text.