Aerosol formulation for the inhalation of beta agonists
AssigneeBoehringer Ingelheim International GmbH
InventorsKirsten RADAU, Michael AVEN, Rainer WEITZEL
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Abstract
The present invention relates to a propellant-free aerosol formulation which contains one or more compounds of general formula 1, wherein the groups R1, R2, R3 and X− may have the meanings indicated in the claims and in the specification, and two further active substances 2 and 3, for inhalation.
Claims22
Medicament formulation comprising:
- as active substance a compound of the formula 1
- wherein
- X− denotes a mono- or polysubstituted negatively charged anion;
- as active substance 2 ciclesonide, or a metabolite thereof;
- as active substance 3 a tiotropium salt;
- at least one pharmacologically acceptable acid;
- and
- an antioxidant as a further pharmacologically acceptable excipient, wherein said antioxidant is butylhydroxytoluene.
-15. (canceled)
-22. (canceled)
Medicament formulation comprising:
- as active substance a free base of formula 1′
- as an active substance 2 ciclesonide, or a metabolite thereof;
- as an active substance 3 a tiotropium salt;
- at least one pharmacologically acceptable acid;
- and
- an antioxidant as a further pharmacologically acceptable excipient, wherein said antioxidant is butylhydroxytoluene.
-31. (canceled)
Medicament formulation according to claim 31, wherein said active substance 3 is in the form of the tautomers, enantiomers, mixtures of the enantiomers, racemates, solvates or hydrates thereof.
(canceled)
Dependencies are inferred from the claim text.