Buccal and/or sublingual therapeutic formulation
AssigneeLingual Conseqna Pty Ltd.
InventorsAlistair Cumming, Lance Sparrow, David Kannar
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Abstract
A buccal and/or sublingual formulation comprising one or more active compounds; and a buccal matrix which releases the active compounds at a predetermined rate for transport across the buccal and/or sublingual membranes, wherein the rate of release of the active compounds is either (A) the same or substantially the same rate at which the active compounds are transported across the buccal and/or sublingual membranes; or (B) a rate which releases the active compounds over an extended period as required by the therapeutic affect or treatment window for those active compounds.
Claims4
A buccal and/or sublingual formulation comprising:
- (a) one or more active compounds;
- and
- (b) a matrix which releases the active compounds at a predetermined rate for transport across the buccal and/or sublingual membranes, the matrix comprising one or more compounds selected predominantly from the group consisting of:
- (i) taste masking agents,
- (ii) enhancers,
- (iii) complexing agents, and
- mixtures thereof;
- and
- (c) other pharmaceutically acceptable carriers and/or excipients,
- wherein the rate of release of the active compounds is either (A) the same or substantially the same rate at which the active compounds are transported across the buccal and/or sublingual membranes;
- or (B) a rate which releases the active compounds so as to provide a higher area under the curve (AUC) value when compared with equivalent compounds in a swallow formulation on a dose normalised basis.
A method for reducing the amount of active compound used to achieve an effect in an individual patient as compared to a typical compound that is swallowed, the method comprising administering to an individual a buccal and/or sublingual formulation comprising
- (a) one or more active compounds;
- and
- (b) a matrix which releases the active compounds at a predetermined rate for transport across the buccal and/or sublingual membranes, the matrix comprising one or more compounds selected predominantly from the group consisting of:
- (i) taste masking agents,
- (ii) enhancers,
- (iii) complexing agents, and
- mixtures thereof;
- and
- (c) other pharmaceutically acceptable carriers and/or excipients,
- wherein the rate of release of the active compounds is either (A) the same or substantially the same rate at which the active compounds are transported across the buccal and/or sublingual membranes;
- or (B) a rate which releases the active compounds so as to provide a higher area under the curve (AUC) value when compared with equivalent compounds in a swallow formulation on a dose normalised basis.
Dependencies are inferred from the claim text.