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US 2012/0058960 A1Published application
Feedback prodrug
AssigneeUniversity of Georgia Research Foundation, Inc.
InventorsGeert-Jan BOONS, Jun Guo
Life of this patent
Estimating the term…
Abstract
Compounds and methods for use in selectively inhibiting a lytic enzyme based on feedback inhibition are described. The conjugated compound serves as a substrate for a lytic enzyme. Cleavage of the conjugated compound by the lytic enzyme releases an inhibitor of the enzyme.
Claims12
A conjugated compound comprising:
- a first constituent comprising an enzymatic substrate;
- and
- a second constituent covalently linked to the first constituent, the second constituent comprising an inhibitor moiety that, when released from the conjugated compound, inhibits the activity of an enzyme;
- wherein the covalent linkage between the first and second constituents can be cleaved by the enzyme to release the inhibitor moiety.
1 more element
Dependencies are inferred from the claim text.