Diaza Heterocyclic Compounds for Phototherapy

A method of using a phototherapeutic agent, the method comprising:

• (i) administering a therapeutically effective amount of a phototherapeutic agent to a subject, the phototherapeutic agent comprising a the compound being of the formula (FX1):
• and (ii) exposing the phototherapeutic agent administered to the patient to electromagnetic radiation;
• wherein
• wherein ring C is:
• each of L1-L6, if present, is independently C1-C10 alkylene, C3-C10 cycloalkylene, C2-C10 alkenylene, C3-C10 cycloalkenylene, C2-C10 alkynylene, ethenylene, ethynylene, phenylene, 1-aza-2,5-dioxocyclopentylene, —(CH2CH2O)m—, —(CHOH)m—, or 1,4-diazacyclohexylene;
• each of W1 and W6 is independently a single bond, —(CH2)n—, —(HCCH)n, —O—, —S—, —SO—, —SO2—, —SO3—, —OSO2—, —NR7—, —CO—, —COO—, —OCO—, —OCOO—, —CONR8—, —NR9CO—, —OCONR10—, —NR11COO—, —NR12CONR13—, or —NR14CSNR15—;
• each of W2-W5 is independently a single bond, a double bond, —(CH2)n—, —(HCCH)n—, —O—, —S—, —SO—, —SO2—, —SO3—, —OSO2—, —NR7—, —CO—, —COO—, —OCO—, —OCOO—, —CONR8—, —NR9CO—, —OCONR10—, —NR11COO—,—NR12CONR13—, or —NR14CSNR15—;
• each of R′ and R6 is independently hydrogen, C1-C20 alkyl, C3-C20 cycloalkyl, C5-C30 aryl, C5-C30 heteroaryl, C1-C20 acyl, C2-C20 alkenyl, C2-C20 alkynyl, C5-C20 alkylaryl, C1-C6 alkoxycarbonyl, halo, halomethyl, dihalomethyl, trihalomethyl, —CN, —CO2R16, —CONR17R18, —COR19, —NO2, —SOR20, —OSR21, —SO2R22, —SO2OR23, —SO2NR24R25, —PO3R26R27, —OR28, —SR29, —NR30R31, —NR32COR33, —(CHOH)mR34, —(CH2CH2O)mR35, —CH(R36)CO2H, —CH(R37)NH2, a dye, or Bm;
• each of R2-R5 is independently hydrogen, C1-C20 alkyl, C3-C20 cycloalkyl, C6-C30 aryl, C5-C30 heteroaryl, C1-C20 acyl, C2-C20 alkenyl, C2-C20 alkynyl, C5-C20 alkylaryl, C1-C6 alkoxycarbonyl, halo, halomethyl, dihalomethyl, trihalomethyl, ═O, ═S, —CN, —CO2R16, —CONR17R18, —COR19, —NO2, —SOR20, —OSR21, —SO2R22, —SO2OR23, —SO2NR24R25, —PO3R26R27, —OR28, —SR29, —NR30R31, —NR32COR33, —(CHOH)mR34, —(CH2CH2O)mR35, —CH(R36)CO2H, —CH(R37)NH2, a dye, or Bm;
• or wherein at least two of R1-R6 combine to form one or more alicyclic or aromatic, carbocyclic or heterocyclic 5 or 6 membered rings;
• wherein at least one of R1-R6 is, or wherein at least two of R1-R6 combine to form, a group corresponding to a naphthalene, naphthoquinone, diphenylmethane, fluorene, anthracene, anthraquinone, phenanthrene, tetracene, naphthacenedione, pyridine, quinoline, isoquinoline, indole, isoindole, pyrrole, imidazole, oxazole, thiazole, pyrazole, pyrazine, pyrimidine, purine, benzimidazole, benzofuran, dibenzofuran, carbazole, acridine, acridone, phenanthridine, thiophene, benzothiophene, dibenzothiophene, xanthene, xanthone, flavone, coumarin, azulene, azaazulene, anthracycline, phenylxanthene, phenothiazine, phenoselenazine, cyanine, indocyanine, sguaraine, dipyrrolo pyrimidone, azo dye, rhodamine, phenoxazine, triphenyl methane dye, benzoindole, indocarbocyanine, Nile Red dye, or benzoindocarbocyanine;
• each m is independently an integer selected from the range of 1 to 100;
• each n is independently an integer selected from the range of 1 to 10;
• each off, e, h, i, j and k is independently 0 or 1;
• each of R7-R33 is independently hydrogen, C1-C20 alkyl, C5-C30 aryl or C5-C30 heteroaryl;
• each of R34 and R35 is independently hydrogen or C1-C10 alkyl;
• each of R36 and R37 is independently a side chain residue of a natural a-amino acid;
• and
• each Bm is independently an amino acid, a peptide, a protein, a nucleoside, a nucleotide, an enzyme, a carbohydrate, a glycomimetic, an oligomer, a lipid, a polymer, an antibody, an antibody fragment, a mono- or polysaccharide comprising 1 to 50 carbohydrate units, a glycopeptide, a glycoprotein, a peptidomimetic, a drug, a steroid, a hormone, an aptamer, a receptor, a metal chelating agent, a polynucleotide comprising 2 to 50 nucleic acid units, a peptoid comprising 2 to 50 N-alkylaminoacetyl residues, a glycopeptide comprising 2 to 50 amino acid and carbohydrate units, or a polypeptide comprising 2 to 30 amino acid units.