Detection of neuropeptides associated with pelvic pain disorders and uses thereof
AssigneesUniversity of Vermont and State Agricultural College, University of Rochester
InventorsRonald W. Wood, Jay Reeder, Edward M. Schwarz, Edward M. Messing, Susan R. Schoen, Margaret A. Vizzard, Ian Dickerson
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Abstract
Diagnostic assessment and therapeutic treatment of pelvic pain disorders, including bladder disorders, bowel disorders, and/or reproductive tissue or organ disorders that are characterized by increased expression of the neuropeptides CGRP and/or PACAP. Additionally, applicants have developed a transgenic non-human model for pelvic pain disorders, where the transgenic animal expresses in bladder sensory neurons a recombinant neuropeptide implicated in the pelvic pain disorder.
Claims20
A method of diagnosing interstitial cystitis comprising:
- measuring a level of CGRP in a sample obtained from a patient having a symptom of interstitial cystitis;
- and
- determining if the measured level of CGRP in the sample is elevated in relation to a standard level of CGRP in a normal asymptomatic population, wherein the measured level of CGRP that is elevated relative to the standard level in combination with the symptom indicates the diagnosis of a interstitial cystitis.
A method of diagnosing a pelvic pain disorder comprising:
- measuring a level of CGRP in a sample obtained from a patient having a symptom of a pelvic pain disorder;
- and
- determining if the measured level of CGRP in the sample is elevated in relation to a standard level of CGRP in a normal asymptomatic population, wherein the measured level of CGRP that is elevated relative to the standard level in combination with the symptom indicates the diagnosis of a pelvic pain disorder.
A method of treating a pelvic pain disorder in a patient comprising providing a CGRP antagonist and administering the CGRP antagonist to a patient in an amount effective to treat the pelvic pain disorder.
Dependencies are inferred from the claim text.