Bone morphogenetic protein 2 (bmp2) variants with reduced bmp antagonist sensitivity
AssigneeHaase Investments UG
InventorsPetra Seemann, Stefan Mundlos, Carsten Reissner, Georg Duda, Julia Zimmer
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Abstract
The present invention is directed to an isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No. 1, characterized in that said amino acid sequence comprises at least two amino acid substitutions characterized in that a first amino acid substitution occurs at a position corresponding to N59, S88, E94, V99, K101 and/or N102 of SEQ ID No. 1 and to uses thereof.
Claims15
An isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No. 1, wherein said amino acid sequence comprises at least two amino acid substitutions, wherein a first amino acid substitution occurs at a position corresponding to N59, S88, E94, V99, K101 and/or N102 of SEQ ID No. 1.
Dependencies are inferred from the claim text.