US 2012/0058909 A1 · IL-17 HOMOLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF

Il-17 homologous polypeptides and therapeutic uses thereof

OwnerJian Chen, Elleri Filvaroff +18inventors

InventorsJian Chen, Elleri Filvaroff, Sherman Fong, Dorothy French, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hilian, Sarah G. Hymowitz, Hanzhong Li, James Pan, Melissa A. Starovasnik, Daniel Tumas, Menno Van Lookeren, Richard Vandlen, Colin K. Watanabe, P. Mickey Williams, William I. Wood, Daniel G. Yansura

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Abstract

The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

Claims2

Dependent claims

A method for detecting the presence of tumor in an mammal, said method comprising comparing the level of expression of

(i) the polypeptide having the amino acid sequence of SEQ ID NO:18;
or
(ii) the polypeptide encoded by the the full-length coding sequence of the cDNA deposited under ATCC accession number PTA-2591
in (a) a test sample of cells taken from said mammal and (b) a control sample of normal cells of the same cell type, wherein a higher level of expression of said polypeptide in the test sample as compared to the control sample is indicative of the presence of tumor in said mammal.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

13/269,984Filed 10 Oct 2011

Priority

11 Jan 2000

Published

8 Mar 2012

Term ends

Not estimatedThe source records don’t support an estimate.

Classification33 codes

C07K 16/244
Against cytokines, lymphokines or interferons: interleukins [IL]
A61P 1/00
Drugs for disorders of the alimentary tract or the digestive system
A61P 11/06
Drugs for disorders of the respiratory system: antiasthmatics
A61P 17/00
Drugs for dermatological disorders

Family

Application60/175,481Us provisional application · filed 11 Jan 2000

Application09/747,259Continuation in part · filed 20 Dec 2000

Application09/816,744Continuation in part · filed 22 Mar 2001

Application09/854,280Continuation in part · filed 10 May 2001

Application09/854,208Continuation in part · filed 10 May 2001

Application09/874,503Continuation in part · filed 5 Jun 2001

Application09/908,827Continuation in part · filed 18 Jul 2001

Application09/918,585Continuation in part · filed 30 Jul 2001

Application09/929,404Continuation in part · filed 13 Aug 2001

Application09/931,836Continuation in part · filed 16 Aug 2001

Application10/000,157Continuation · filed 30 Oct 2001

Application10/617,573Continuation · filed 11 Jul 2003

Application12/549,497Continuation · filed 28 Aug 2009

Application13/269,984Continuation

Application10/000,157Continuation in part

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From the US filing history. Foreign family members aren’t listed.