Cytosolic Delivery of Materials with Endosome-Disrupting Colloids

A composition comprising a nanocrystal-cationic core-shell polymer colloid comprising a core polymer having an outer shell and a nanocrystal conjugated to or coating the shell,

• wherein the core of the cationic core-shell polymer colloid comprising a polymer of core monomers, wherein a first core monomer, having the formula R1C(CH2)—C(O)—R2—R3—N(R4)R5, wherein R1 is H or alkyl, R2 is O or NH, R3 is an alkyl and R4 and R5 are H or alkyl, is crosslinked to a second core monomer, having the formula R1C(CH2)—C(O)—R2—CH2—(CH2—O—CH2)n—CH2—R2—C(O)—C(CH2)R1, wherein R1 is H or alkyl, R2 is O or NH, and n is 1 to 50;
• wherein outer shell comprising polymer of shell monomer and core monomers, wherein the shell monomer having the formula R1C(CH2)—C(O)—R2—R3—N(R4)R6, wherein R1 is H or alkyl, R2 is O or NH, R3 is an alkyl, R4 is H or alkyl, and R6 is H, alkyl, acyl or C═(NH)NH2 and a second shell monomer having the formula R1C(CH2)—C(O)—R2—CH2—(CH2—O—CH2)n—CH2—R2—C(O)—C(CH2)R1, wherein R1 is H or alkyl, R2 is O or NH, and n is 1 to 50, wherein the second core monomer and second shell monomer can be the same or different;
• wherein the nanocrystal comprising a nanocrystal core and nanocrystal shell of any Groups I, II, III, VI, V, VI and/or lanthanide element and binary or ternary compounds, alloys or mixtures thereof.