Platelet aggregation using a microfluidics device

A diagnostic method comprising:

• passing a bilogical sample through a icrofluidics device comprising:
• a channel configured for passage of the biological sample, the channel comprising a protrusion configured to induce an upstream region of shear acceleration coupled to a downstream region of shear deceleration and defining there-between a region of peak rate of shear, the downstream region of shear deceleration defining a zone of platelet aggregation;
• and
• platelet detection means for detecting aggregation of platelets in the zone of aggregation as a result of passage of the biological sample through the channel;
• and
• providing an indication of the detected aggregation of platelets.

A kit for use in monitoring platelet function, comprising packaging material comprising:

• (i) a microfluidics device;
• and
• (ii) instructions for indicating that the microfluidics device is to be used in a system for monitoring platelet function;
• and
• wherein the microfluidics device comprises:
• a channel configured for passage of the biological sample, the channel comprising a protrusion configured to induce an upstream region of shear acceleration coupled to a downstream region of shear deceleration and defining there-between a region of peak rate of shear, the downstream region of shear deceleration defining a zone of platelet aggregation;
• and
• platelet detection means for detecting aggregation of platelets in the zone of aggregation as a result of passage of the biological sample through the channel.