Methods and materials for assessing a mammal's susceptibility for venous thromboembolism
OwnerJohn A. Heitinventor
Life of this patent
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Abstract
This document provides methods and materials involved in assessing a mammal (e.g., a human) for a susceptibility to develop venous thromboembolism. For example, methods and materials for using a genetic variation in an ABO nucleic acid (e.g., rs2519093) to assess an individual's risk for developing venous thromboembolism are provided.
Claims16
A method for identifying a mammal having increased susceptibility to develop venous thromboembolism, wherein said method comprises:
- (a) determining whether or not a mammal contains a T allele of rs2519093, and
- (b) classifying said mammal as having an increased susceptibility to develop venous thromboembolism if said mammal contains said T allele.
A method for identifying a mammal having increased susceptibility to develop venous thromboembolism, wherein said method comprises:
- (a) detecting the presence of a mutant T allele of rs2519093 in a mammal, and
- (b) classifying said mammal as having an increased susceptibility to develop venous thromboembolism based at least in part on the presence of said mutant T allele.
A method for identifying a mammal having increased susceptibility to develop venous thromboembolism, wherein said method comprises:
- (a) detecting the presence of a mutant T allele of rs2519093 in a mammal,
- (b) detecting the presence of a G allele of rs6025, a G allele of rs1799963, or a mutant allele of rs8176719, and
- (c) classifying said mammal as having an increased susceptibility to develop venous thromboembolism based at least in part on the presence of said mutant T allele and the presence of said G allele of rs6025, said G allele of rs1799963, or said mutant allele of rs8176719.
A method for identifying a mammal having increased susceptibility to develop venous thromboembolism, wherein said method comprises:
- (a) determining whether or not a mammal contains as allele of rs3087505, rs4253399, rs3917862, rs5759224, rs1073897, rs9328375, rs7538157, rs16861990, rs2038024, rs495828, or rs8176719 that is associated with a susceptibility to develop venous thromboembolism, and
- (b) classifying said mammal as having an increased susceptibility to develop venous thromboembolism if said mammal contains said allele.
A method for identifying a mammal having increased susceptibility to develop venous thromboembolism, wherein said method comprises:
- (a) detecting the presence of, in a mammal, an allele of rs3087505, rs4253399, rs3917862, rs5759224, rs1073897, rs9328375, rs7538157, rs16861990, rs2038024, rs495828, or rs8176719 that is associated with a susceptibility to develop venous thromboembolism, and
- (b) classifying said mammal as having an increased susceptibility to develop venous thromboembolism based at least in part on the presence of said mutant T allele.
Dependencies are inferred from the claim text.