Robust Hybrid Thin Films that Incorporate Lamellar Phospholipid Bilayer Assemblies and Transmembrane Proteins
AssigneeStc.Unm
InventorsGabriel P. Lopez, Plamen Atanasov, Gautam Gupta
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Abstract
The present disclosure provides various novel methods for forming hybrid thin films that contain multi-lamellar assemblies of phospholipid bilayers and can incorporate proteins, polypeptides, biological complexes, transmembrane proteins and other membrane-associated compounds. The present disclosure further provides uses for such bilayer lipid membranes including, biosensing for medical diagnosis and environmental monitoring, chemical and biological warfare agent sequestration, actuator development, and bio-fuel cell development.
Claims18
An artificial hybrid lipid-polymer membrane comprising a biomolecular complex, wherein the membrane exhibits substantially constant d-spacing.
The hybrid lipid-polymer membrane of 1, wherein the lipid is 1,2-dimyristoyl-sn-glycero-3-phosphocholine, 1,2-dimyristoyl-sn-glycero-3-pho sphoethanolamine, 1,2-dimyristo yl-sn-glycero-3-[phospho-rac-(1-glycerol)] (S odium Salt), 1-myristoyl-2-hydroxy-sn-glycero-3-phosphocholine (14:0 Lyso PC), 1,2-dioleoyl-sn-glycero-3-phosphocholine, 1-oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, L-α-phosphatidylcholine or 1,1′,2,2′-tetramyristoyl cardiolipin.
Dependencies are inferred from the claim text.