Methods for treating cancer and other pathological proliferating disorders by inhibiting mitosis using pyrrolo[2,3-d]pyrimidines

A method of treating cancer and other pathological proliferating conditions, the method comprising:

• administering an effective amount of at least one compound having the formula (16):
• wherein X is selected from the group consisting of a lower alkyl group, a heteroalkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, an arylalkyl group, and a heteroarylalkyl group;
• wherein R1 is selected from the group consisting of hydrogen, a lower alkyl group, a heteroalkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, an arylalkyl group, and a heteroarylalkyl group;
• wherein R2 is selected from the group consisting of hydrogen, a lower alkyl group, a plurality of lower alkyl groups, a heteroalkyl group, a plurality of heteroalkyl groups, an alkoxy group, a plurality of alkoxy groups, a substituted or unsubstituted aryl group, a plurality of substituted or unsubstituted aryl groups, a substituted or unsubstituted heteroaryl group, and a plurality of substituted or unsubstituted heteroaryl groups;
• wherein R3 is selected from the group consisting of zero, a lower alkyl group, a heteroalkyl group, an alkenyl group, and a heteroalkenyl group;
• and
• wherein R4 is selected from the group consisting of a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, an arylalkyl group, a heteroarylalkyl group, and hydrogen, and R4 is hydrogen when R3 is zero;
• and
• administering an effective amount of an additional chemotherapeutic agent.