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AssigneeBASF SE
InventorsAndreas Buthe, Andreas Hafner, Franz Kaufmann, Babette Fiedler, Guido Meurer, Gordon Bradley
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The present invention provides the use of surface active proteins, especially class I and class II hydrophobins, in topically applied pharmaceutical formulations. The invention is particularly directed to topically applied pharmaceutical products for enhancing the penetration to achieve a transungual delivery of a prophylactically and/or therapeutically effective amount of an active ingredient (drug) to a patient (including animals and humans) into and/or through a nail, of the animal or human body, in order to treat one or more of a variety of diseases or disorders. Related embodiments of the invention are also disclosed.
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A method of enhancing the penetration of at least one active ingredient into and/or through a nail of a patient, said method comprising admixing a surface active protein to a pharmaceutical formulation together with one or more active ingredients and optionally one or more pharmaceutically acceptable carriers and/or ingredients, and topically administering the resulting pharmaceutical formulation to said patient.
A pharmaceutical formulation, comprising at least one pharmaceutically active ingredient and 0.001 to 5%, based on the weight of the pharmaceutical formulation, of a surface active protein together with at least one further pharmaceutically acceptable carrier.
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Dependencies are inferred from the claim text.