Liver-specific Nanocapsules and Methods of Using
OwnerBetsy T. Kren, Clifford J. Steer +1inventors
InventorsBetsy T. Kren, Clifford J. Steer, Gretchen M. Unger
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Abstract
This disclosure describes liver-specific nanocapsules for specifically targeting liver cells. This disclosure also provides methods of using such liver-specific nanocapsules to deliver one or more cargo moieties to the liver cells.
Claims24
1-23. (canceled)
A composition of nanocapsules comprising at least one liver-specific targeting moiety and at least one cargo moiety, wherein said at least one targeting moiety is non-covalently associated with said nanocapsules, wherein said at least one cargo moiety is encapsulated by said nanocapsules, and wherein said nanocapsules have an average diameter of less than 50 nanometers.
A method of targeting a pharmaceutical agent to liver cells, wherein the method comprises administering to a subject a composition of liver-targeted nanocapsules comprising:
- a liver cell targeting moiety comprising an asialoorosomucoid (ASOR) polypeptide that-is non-covalently associated with the nanocapsules, and
- a cargo moiety comprising a pharmaceutical agent that is encapsulated by the nanocapsules,
- wherein the nanocapsules have an average diameter of less than 50 nanometers.
Dependencies are inferred from the claim text.