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AssigneeThe Scripps Research Institute
InventorsRalph A. Reisfeld, Rong Xiang, Yunping Luo, Debbie Liao, Ze Liu, Tingmei Chen, Si Chen, Dan Lu
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The present invention provides an aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises (a) a legumain-targeting lipid component, (b) a zwitterionic lipid component; (c) an amino-substituted lipid component; (d) a neutral lipid component; and (e) polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalenetly attached to a legumain-binding moiety.
An aqueous tumor-targeting liposome nanoparticle composition comprising a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of liposome nanoparticles dispersed in an aqueous carrier, and optionally encapsulating an anti-tumor chemotherapeutic agent within the liposome nanoparticles;
An aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles optionally encapsulating an anti-cancer chemotherapeutic agent;
An aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles encapsulating an anti-cancer chemotherapeutic agent;
Dependencies are inferred from the claim text.