Fabrication of interconnected model vasculature
AssigneesWilliam Marsh Rice University, University of Pennsylvania
InventorsJennifer L. West, Christopher S. Chen, Jordan S. Miller, Michael T. Yang
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Abstract
Methods of fabricating a substantially interconnected model vasculature, as well as compositions formed from such methods are provided. In some embodiments, the methods may comprise forming a non-woven fiber network comprising a plurality of fibers and a void space; backfilling the void space of the fiber network; and removing the fibers to form a substantially interconnected vascular network.
Claims45
A method comprising:
- forming a non-woven fiber network comprising a plurality of fibers and a void space;
- backfilling the void space of the non-woven fiber network;
- and
- removing the plurality of fibers to form a substantially interconnected vascular network comprising fluidic channels.
A method of forming a substantially interconnected vascular network, comprising:
- forming a fiber network comprising a plurality of fibers and a void space;
- surface coating the fiber network with a surface coating material;
- backfilling the void space of the fiber network with a biomaterial;
- and
- removing the fibers to form a substantially interconnected vascular network comprising fluidic channels.
A method comprising:
- providing a fiber network, the fiber network comprising a plurality of fibers;
- and
- coating at least a portion of the surface of the fibers with a surface coating material so as to at least partially inhibit wet etching or dissolution of the fiber network.
A composition comprising:
- a biomaterial;
- and
- a plurality of substantially interconnected fluidic channels disposed within the biomaterial wherein the fluidic channels have a total volumetric density of between about 5% and 95% of the biomaterial and wherein the distance between the fluidic channels is no more than about 1 mm.
A composition comprising:
- a plurality of fibers arranged in a substantially interconnected network in which the distance between the fibers is no more than about 1 mm.
Dependencies are inferred from the claim text.