Stable, spray dryed, immunogenic, viral compositions
AssigneeAeras Global TB Vaccine Foundation
InventorsTom Han Jin, Eric I-Fu Tsao
Life of this patent
Estimating the term…
Abstract
Viruses, and particularly genetically engineered, replication deficient viruses such as adenoviruses, poxviruses, MVA viruses, and baculoviruses which encode one or more antigens of interest, such as TB, malarial, and HIV antigens, are spray dried with a mannitol-cyclodextrin-trehalose-dextran (MCTD) to form a powder where the viability of the viruses are maintained at a suitable level for mass vaccinations after spray drying, and where the viability of the viruses are maintained at suitable level over a period of storage time, even in the presence of humidity.
Claims21
An immunogenic composition, comprising:
- one or more live viruses in a powder formulation spray dried from a composition comprising mannitol at 10-150 mg/ml, cyclodextrin at 0.1-10 mg/ml, trehalose at 0.2-30 mg/ml, and dextran at 0.1-30 mg/ml.
A method of forming an immunogenic composition, comprising:
- spray drying one or more live viruses from a composition comprising mannitol at 10-150 mg/ml, cyclodextrin at 01.-10 mg/ml, trehalose at 0.2-30 mg/ml, and dextran at 0.1-30 mg/ml to form a spray dried powder containing said one or more live viruses.
Dependencies are inferred from the claim text.