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US 2012/0058156 A1Published application
Activated leukocyte composition and uses for wound healing
AssigneeMacrocure Ltd.
InventorsMitchell Shirvan, Eilat Shinar, Orit Frenkel, Adi Zuloff-Shani, Marina Bubis, Eilat Bain, Irene Ginis
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Abstract
Disclosed are therapeutic, blood-derived activated leukocyte compositions, methods of making them, and methods of using the compositions to repair or promote the prevention and healing of wounds.
Claims44
A method for making an activated leukocyte composition comprising:
- a) incubating human leukocytes for a period of time so that the leukocytes transition from a quiescent to a functionally active state;
- b) subjecting the leukocytes to hypo-osmotic shock;
- and
- c) adding to the leukocytes of step b) a salt solution in an amount which restores isotonicity.
1 more element
A method for activating leukocytes comprising:
- a) obtaining leukocytes from human blood;
- and
- b) incubating the human leukocytes for a period of time so that the leukocytes transition from a quiescent to a functionally active state.
A composition comprising activated leukocytes, wherein the composition comprises:
- a) about 40% to about 90% granulocytes;
- b) about 5% to about 20% monocytes;
- and
- c) about 5% to about 30% lymphocytes.
1 more element
Dependencies are inferred from the claim text.