Chimeric newcastle disease viruses and uses thereof
AssigneesMount Sinai School of Medicine, Memorial Sloan Kettering Cancer Center
InventorsPeter Palese, Adolfo Garcia-Sastre, Dmitriy Zamarin, Yuman Fong
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Abstract
Described herein are chimeric Newcastle disease viruses engineered to express a heterologous interferon antagonist and compositions comprising such viruses. The chimeric Newcastle disease viruses and compositions are useful in the treatment of cancer.
Claims22
A chimeric Newcastle disease virus (NDV), comprising a packaged genome which encodes a heterologous interferon antagonist and a modified F protein with a mutated cleavage site, wherein the heterologous interferon antagonist and the modified F protein are expressed by the virus.
(canceled)
A method for treating cancer in a subject, comprising administering to a subject in need thereof a pharmaceutical composition comprising a first chimeric NDV and a pharmaceutically acceptable carrier, wherein the first chimeric NDV comprises a packaged genome which encodes a heterologous interferon antagonist, so that the heterologous interferon antagonist is expressed by the virus.
(canceled)
Dependencies are inferred from the claim text.