Novel multimodular assembly useful for intracellular delivery
AssigneeInstitut National De La Sante Et De La Recherche Medicale (Inserm)
InventorsBruno Pitard, Charles Tellier, Corinne Miral, Emilie Letrou-Bonneval
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Abstract
A stabilized multimodular assembly for intracellular delivery comprising a complex of at least one cationic transfection agent and of at least one negatively charged macromolecule, wherein the complex has a theoretical charge ratio ranging from about 0 to about 4, and an efficient amount of at least one amphiphilic block co-polymer acting as a steric colloidal stabilizer with respect to the complex, the block co-polymer having hydrophilic and hydrophobic blocks wherein at least one hydrophilic block is conjugated with at least one targeting ligand.
Claims15
A stabilized multimodular assembly useful for intracellular delivery comprising:
- a complex of at least one cationic transfection agent and of at least one negatively charged macromolecule, wherein said complex has a theoretical charge ratio ranging from about 0 to about 4, and
- an efficient amount of at least one amphiphilic block co-polymer acting as a steric colloidal stabilizer with respect to said complex, said amphiphilic block co-polymer comprising hydrophilic and hydrophobic blocks wherein at least one hydrophilic block is conjugated with at least one targeting ligand.
Dependencies are inferred from the claim text.