NON-SPLICING VARIANTS OF gp350/220
AssigneeMedImmune, LLC
InventorsRichard SPAETE, Winthrop Jackman
Life of this patent
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Abstract
Compositions comprising gp350 variant DNA and amino acid sequences are provided, as are vectors and host cells containing such sequences. Also provided is a process for producing homogeneous gp350 protein recombinantly and in the absence of production of gp220 protein, pharmaceutical compositions containing such protein and prophylactic treatments making use of such proteins.
Claims13
An isolated DNA sequence that codes on expression for an homogeneous gp350 protein.
A homogeneous gp350 protein, wherein one or more of the native nucleotides encoding the donor splice site and acceptor splice site are replaced with substitute nucleotide(s) different from said native nucleotide(s) which preserve the amino acid sequence of said donor and acceptor sites.
Dependencies are inferred from the claim text.