Pta089 protein
AssigneeOxford Biotherapeutics Ltd
InventorChristian Rohlff
Life of this patent
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Abstract
The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of bladder cancer, colorectal cancer, head and neck cancer, kidney cancer, liver cancer, lung cancer, prostate cancer or skin cancer, for monitoring the effectiveness of bladder cancer, colorectal cancer, head and neck cancer, kidney cancer, liver cancer, lung cancer, prostate cancer or skin cancer treatment, and for drug development.
Claims25
A method for treating or preventing bladder cancer, colorectal cancer, head and neck cancer, kidney cancer, liver cancer, lung cancer, prostate cancer or skin cancer which comprises administering to a subject in need thereof a therapeutically effective amount of a composition comprising an affinity reagent capable of specific binding to PTA089 or a fragment thereof, and a pharmaceutically acceptable diluent or carrier, wherein PTA089 is overexpressed in said cancers.
An affinity reagent capable of specific binding to PTA089 or a fragment thereof, which contains or is conjugated to a therapeutic moiety.
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A monoclonal antibody capable of specific binding to PTA089 or a fragment thereof, which has cytotoxicity against PTA089 antigen expressing cells in the presence of a human complement or in the presence of human immune effector cells.
A method of detecting, diagnosing and/or screening for or monitoring the progression of bladder cancer, colorectal cancer, head and neck cancer, kidney cancer, liver cancer, lung cancer, prostate cancer or skin cancer or of monitoring the effect of an anti-bladder cancer, anti-colorectal cancer, anti-head and neck cancer, anti-kidney cancer, anti-liver cancer, anti-lung cancer, anti-prostate cancer or anti-skin cancer drug or therapy in a subject which comprises detecting the presence or level of PTA089, or one or more fragments thereof, or the presence or level of nucleic acid encoding PTA089 or the presence or level of the activity of PTA089 or which comprises detecting a change in the level thereof in said subject.
Dependencies are inferred from the claim text.