Methods and compositions for treating lupus
AssigneeNatrogen Therapeutics International, Inc.
InventorsLonggui Wang, Simon K. Mencher
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Abstract
The invention relates to compositions and methods for treating lupus. The methods typically comprise the step of administrating one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, such as, Meisoindigo and NATURA in an amount sufficient to treat the lupus; preferably by modulating cytokine expression. Preferably the compound is in an amount less than sufficient to substantially inhibit cyclin dependent kinases.
Claims32
A method of treating an animal with lupus, the method comprising the step of administering to the animal in need of such treatment at least one compound selected from the group of:
- Meisoindigo, tri-acetylated glyco-Meisoindigo (pro-drug) or NATURA, shown as Formulas (IV), (V), and (VI) respectively,
- wherein the compound is administered is in an amount sufficient to treat lupus.
A method of treating lupus, the method comprising the step of administering to an animal in need of such treatment at least a first and a second compound, wherein the first compound is selected from the group of:
- Meisoindigo, tri-acetylated glyco-Meisoindigo (pro-drug) or NATURA, shown as Formulas (IV), (V), and (VI) respectively,
- wherein the second compound is selected from the group consisting of:
- anti-inflammatory agent, corticosteroid, immune suppressant, or biologic drug;
- and
- wherein the first compound is administered in an amount sufficient to treat lupus.
A composition for treating lupus, the compositions comprising an active compound, an agent, and a pharmaceutically acceptable carrier, wherein the active compound is selected from the group of:
- Meisoindigo, tri-acetylated glyco-Meisoindigo (pro-drug) or NATURA, shown as Formulas (IV), (V), and (VI) respectively,
- and the agent is selected from the group consisting of:
- an anti-inflammatory agent, corticosteroid agent, immune suppressant agent, or a biologic drug.
A method of treating an animal with nephritis, the method comprising the step of administering to the animal in need of such treatment at least one compound selected from the group of:
- Meisoindigo, tri-acetylated glyco-Meisoindigo (pro-drug) or NATURA, shown as Formulas (IV), (V), and (VI) respectively,
- wherein the compound is administered is in an amount sufficient to treat nephritis.
Dependencies are inferred from the claim text.